DMG dosage was equivalent to 6.94 mg to 10.41 mg per kilogram body weight. Patients and Methods: The 106 autistic children were from an autism society and were matched into two groups according to sex, age, body weight, and language ability, and were randomly assigned to an experimental group taking DMG or a control group taking a placebo, with identical packaging in both groups. © 2008 Wiley-Liss, Inc.Objective: A double blind study of dimethylglycine (DMG) treatment in autistic children. Additive genetic factors were more influential in females than males. Autistic traits were highly heritable in twins with even broad spectrum of autism, corresponding to the results of early studies based on classical autism. There was no evidence for the existence of sex-specific genetic influences. With this AE model, the estimated heritability was 0.73 for males and 0.87 for females, based on the continuous CARS scores. A best fitting model of causal influences on autistic traits measured continuously, incorporating additive genetic (A) and non-shared environmental influences (E), was generated. The obtained CARS scores were subjected to structural equation modeling (SEM), incorporating sex differences for each causal influence ascertainment correction, using the Mx software. The CARS test was performed on 45 twin pairs (19 monozygotic, 26 dizygotic) detected with a regional routine screening system. In order to adjust for recent concepts of autism, we employed criteria for the broad spectrum of disease and the childhood autism rating scale (CARS) for quantitative assessment. An investigation of genetic structures underlying autistic traits was performed with samples from twins for which at least one proband had been ascertained as having autism spectrum disorders (ASDs) in our catchment area.
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